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The addition of maintenance olaparib (Lynparza) to bevacizumab (Avastin) appeared to elicit better progression-free survival (PFS) in patients with BRCA-mutant high-grade ovarian cancer, with particular benefit observed in those with mutations located in the DNA-binding domain (DBD) of BRCA1/2, according to findings from an exploratory. PAOLA-1/ENGOT-ov25 (NCT02477644) demonstrated a significant progression-free survival (PFS) benefit with maintenance olaparib plus bevacizumab versus placebo plus bevacizumab in newly diagnosed, advanced ovarian cancer. We are here to give you a better experience with our accurate football predictions. 24/7 customer service. They offer you a wide array of correct predictions that you can rely on blindly. 12. They offer you a wide array of correct predictions that you can rely on blindly. 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